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After Murder 2, she has done independent and content driven Hindi films with strong performances like Rave, starring Rajkumar Rao and Divyendu Sharma and Gurudakshina, with Girish Karnad and Rupa Ganguly. Her role was well-received with positive reviews from critics around the media. She played the role of Reshma, a poor college student, who in need of money for her family to survive, chooses to become a part-time prostitute and falls victim to a psychopathic serial killer. She made her Bollywood debut in the 2011 thriller Murder 2, a sequel to the 2004 hit Murder, under the banner of Vishesh Films. After this, she went on to do a negative role in the serial Bidaai, playing the role of Sakshi. Do Saheliyaan aired on Zee TV from March 2010 to July 2010. Her second show was Do Saheliyaan, where she played the role of Maithali, based on the story of best friends set in rural Rajasthan. The series aired on Sony Entertainment Television from September 2007 to March 2008. Panigrahi made her television debut with the show Amber Dhara, where she played the character of Dhara, based on a story of conjoined twins.
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